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Delayed renocolic fistula formation following percutaneous radiofreqency ablation of renal mass: case report and review of the published cases




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We report a case of a 71-year-old man who developed a renocolic fistula 10 months after radiofrequency ablation. At the time of fistula formation there was no evidence of tumor recurrence.

Authors: Douglas, Sean; Ogles, Mitchell; Vick, Kenneth; Pound, Charles R.

Corresponding Author: Douglas, Sean

 

Introduction
Image-guided radiofrequency ablation (RFA) is an established minimally invasive treatment for renal cell carcinoma (RCC) in patients with significant comorbidities or limited renal function (1). Reported complication rates of image-guided RFA are lower than for extirpative surgery, ranging from 0% to 11% for RFA and 14% to 26% for surgical excision (2). Renocolic fistula is a rarely described complication. We present a case of delayed renocolic fistula following radiofrequency ablation of a small renal cell carcinoma and a review of the three previously reported cases.

Case Report

The patient is a 71-year-old white male who was found to have an anterior right lower pole, 2.1 centimeter exophytic renal mass after abdominal computed tomography (CT) for vague abdominal pain. The patient elected to undergo CT guided radiofrequency ablation. Intra-procedural and post-procedural imaging showed no evidence of injury to adjacent organs. At four month follow up the patient had no complaints, and there was no evidence of tumour recurrence on CT scanning. At an unscheduled ten month appointment he reported pneumaturia and had developed a urinary tract infection. CT demonstrated air within the collecting system. The ascending colon was now immediately adjacent to the area of ablation concerning for a raising concern that the patient may have a renocolic fistula. A barium enema demonstrated filling of the right renal pelvis confirming the fistula.

Right partial nephrectomy and right hemicolectomy was performed without intraoperative complication. The collecting system defect was closed with interrupted absorbable sutures and the renal defect was closed with absorbable sutures bolstered with pledgets and Surgiseal. Pathological evaluation of the specimen revealed no residual tumor. His post operative course was complicated by colonic anastomotic leak and intra-abdominal abscesses requiring the placement of percutaneous drains, open debridement, and eventual placement of an end ileostomy over a nine month period. His ileostomy has been reversed. He is doing well with no tumor recurrence 29 months post ablation.

Discussion

We have identified 2 cases of renocolic fistula directly attributable to treatment of a renal tumour, one percutaneous and one surgical assisted, and one further case which was confounded by extensive local tumor recurrence.
In a cohort of 24 patients, Weizer et al reported on one fistula occurring in a 56 year old male with a 1.8 cm left sided anterior upper pole lesion and a solitary kidney who underwent percutaneous RFA. The fistula manifested 7 days post ablation. The renal unit was successfully salvaged with nephrostomy tube decompression and total parenteral nutrition. (3)
Medina et al reported a case of renocolic fistula in a patient with a left solitary kidney who had undergone two previous partial nephrectomies intraoperative RFA (approach not reported). In this case the renocolic fistula manifested 7 days postoperatively as watery diarrhea. The patient was treated with double J stent placement, colonic resection and closure of the renal fistula tract. Four days after repair the patient developed a renoperitoneal fistula and ultimately had to undergo a radical nephrectomy. Pathology demonstrated Fuhrman grade 1/4 clear cell carcinoma. (4)
Uribe reported on a 78 year old man who underwent laparoscopic RFA of a 3 cm left sided lesion that was to be followed by laparoscopic partial nephrectomy (ablate and resect arm of a prospective study). The resection was abandoned due to an intraoperative cardiac arrhythmia and subsequent myocardial infarction. Eight months later the patient’s renal mass had increased in size to 18 cm with invasion through the wall of the colon and fistula formation. Eventual resection revealed a Fuhrman grade 4/4 clear cell carcinoma. In this case of aggressive local recurrence, it is difficult to directly attribute the fistula to the RFA procedure, although it may have played some role. (5)
Of the above two cases without tumor recurrence, renocolic fistula was diagnosed within 7 days of treatment. Our patient was completely asymptomatic until several months post ablation. Post RFA renocolic fistulas seem to manifest with typical signs and symptoms: urinary tract infections, pneumaturia, and watery diarrhea. Standard urological imaging techniques provide confirmation of the suspected diagnosis.
The location of the renal lesion is relevant in preventing bowel injury during RFA. Anterior tumors are more likely to be in contact with intra-abdominal contents and thus increase the risk of bowel injury (1,6). A 5 mm layer of fat has been described as sufficient to insulate the bowel from thermal injury (1,8). Multiple maneuvers have been described to decrease the chance of bowel injury, including patient positioning, levering the tumor with the RFA probe, and injection of sterile fluid to hydrodissect the tumor away from the bowel (1,6). Of the above cases without tumor recurrence, in all, the lesion was located anteriorly, increasing the risk of bowel injury and fistula formation. Some authors (8) have proposed a laparoscopic approach to anterior tumors to decrease the chance of bowel injury and while this may decrease the risk of injury, it is not entirely protective as evidenced by the above cases.

Conclusion
Renocolic fistula formation following radiofrequency ablation is an extremely rare complication. The manifestation of the fistula 10 months following treatment represents a delayed presentation of a previously described adverse event. Surgically assisted RFA may decrease the possibility of fistula formation for anterior tumors but is not entirely protective. Percutaneous RFA is an acceptable minimally invasive treatment option for small renal masses but is not without complications.

fig1snag

Axial CT status post radiofrequency ablation demonstrated no evidence of residual tumor with ample separation between the ablated mass and ascending colon. There is a small perinephric hematoma at the site of ablation.

fig2snag

Axial CT at 10 months post ablation displaying the area of ablation closely contiguous to the ascending colon, as well as air within the collecting system of the right kidney suggesting a fistula.

fig3snag

Barium Enema showing uptake into the right collecting system confirming communication between the ascending colon and the right renal collecting system.

upright

Coronal CT showing fistula formation.

References:
1. Park S, et al. Radiofrequency ablation treatment for renal cell carcinoma: Early clinical experience. Korean J Radiol 2008; 9:340-47.
2. Boss A, Clasen S, et al. Image-guided radiofrequency ablation of renal cell carcinoma. Eur Radiol 2007; 17: 735-33.
3. Weizer AZ, Raj GV, O’Connell M, Robertson CN, Nelson RC, Polascik TJ. Complications after percutaneous radiofrequency ablation of renal tumors. Urology. 2005 Dec;66(6):1176-80.
4. Sáenz Medina J, Redondo González E, Hernández-Atance JM, Crespo Martínez L, Llanes González L, Rendón Sánchez D, Páez Borda A. Renocolic fistula as a complication of radiofrequency in the treatment of renal cell carcinoma. Arch Esp Urol. 2010 Jan-Feb;63(1):74-7.
5. Uribe PS, Costabile RA, Peterson AC. Progression of renal tumors after laparoscopic radiofrequency ablation. Urology. 2006 Nov;68(5):968-71. Epub 2006 Nov 7.
6. Gervais D, Arellano R, Mueller P. Percutaneous radiofrequency ablation of renal cell carcinoma. Eur Radiol 2005; 15: 960-67.
7. Park B, Chan K. Complication of image-guided radiofrequency ablation of renal cell carcinoma: causes, imaging features and prevention methods. Eur Radiol 2009; 19:2180-90.
8. Rhim H, Dodd G 3rd, Chintapalli K, Wood B, Dupuy D, Hvizda J, Sewell P, Goldberg S. Radiofrequency thermal ablation of abdominal tumors: lessons learned from complications. Radiographics 2004; 24:41-52

 

Date added to bjui.org: 24/10/2012

DOI: 10.1002/BJUIw-2012-020-web

 

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