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What’s the diagnosis?

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30 Aug 2019
#BJUI, picture quiz, picture quiz 30-08-19, quiz of the week, What's the Diagnosis
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What’s the diagnosis?




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This image is taken from Dhawiwal et al (BJUI 2019). It schematically shows mechanism of action for immunotherapy for urothelial carcinoma.

Quiz




What checkpoint targets can potentially be blocked and can you name an example?

Show answer

Programmed cell death protein 1 (PD-1) is found on the activated T-cell.
Pembrolizumab and Nivolumab are examples of PD-1 antibodies.

Programmed death ligand 1 (PD-L1) is found on the tumour cell. Various Immune checkpoint inhibitors act on these (anti-PD-L1) e.g. atezolizumab, durvalumab, avelumab.

Cytotoxic T-lymphocyte associated protein4 (CTLA-4) are expressed on T-cells. Examples of anti-CTLA-4 agents are ipilimumab and tremelimumab.

 

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